CD34 Antibody [ICO-115]

• Background:

  This antibody recognizes a single chain, transmembrane, heavily glycosylated protein of 90-120kDa, which is identified as CD34. Its expression is a hallmark for identifying pluripotent hematopoietic stem or progenitor cells. Its expression is gradually lost as lineage committed progenitors differentiate. CD34 is a marker of choice for staining blasts in acute myeloid leukemia. In addition, it is expressed by soft tissue tumors, such as solitary fibrous tumor and gastrointestinal stromal tumor. CD34 expression is also found in vascular endothelium. Additionally, it appears that proliferating endothelial cells overexpress this molecule than the non-proliferating endothelial cells. Anti-CD34 labels > 85% of angiosarcoma and Kaposi’s sarcoma, but shows low specificity.

• NCBI Gene ID:

  947

• Swiss Prot:

  P28906

• Host:

  Mouse

• Reactivity:

  Human, Rat

• Immunogen:

  Blast cells from a chronic myeloid leukemia patient were used as the immunogen for this CD34 antibody.

• Clonality:

  Monoclonal

• Clone:

  ICO-115

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Immunology, Neuroscience, Signal Transduction

• Purification:

  Protein G affinity chromatography

• Concentration:

  0.2 mg/mL

• Buffer:

  PBS with 0.1 mg/ml BSA and 0.05% sodium azide

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.

• Fragment:

  IgG1, kappa

• Symbol:

  CD34

• NCBI Official Name:

  CD34 molecule

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Hematopoietic progenitor cell antigen CD34, CD34, CD34

• Tested Applications:

  WB, Flow, IF

• Physical Properties:

  Liquid