CD3e Antibody

• Background:

  This antibody recognizes the epsilon-chain of CD3 (CD3e), which consists of five different polypeptide chains (designated as gamma, delta, epsilon, zeta, and eta) with MW ranging from 16-28kDa. The CD3 complex is closely associated at the lymphocyte cell surface with the Tcell antigen receptor (TCR) . Reportedly, CD3 complex is involved in signal transduction to the Tcell interior following antigen recognition. The CD3 antigen is first detectable in early thymocytes and probably represents one of the earliest signs of commitment to the Tcell lineage. In cortical thymocytes, CD3 is predominantly intra-cytoplasmic. However, in medullary thymocytes, it appears on the Tcell surface. CD3 antigen is a highly specific marker for Tcells, and is present in majority of Tcell neoplasms.

• NCBI Gene ID:

  916

• Swiss Prot:

  P07766

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat, Primate, Guinea Pig, Hamster, Horse, Mole Rat, Pig, Rabbit, Sheep, Cat, Chicken, Bovine, Dog, Frog, Opossum, Elephant

• Immunogen:

  Amino acids ERPPPVPNPDYEP (156-168) were used as the immunogen for this CD3e antibody.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Immunology, Signal Transduction

• Purification:

  Protein A purified CD3e antibody

• Concentration:

  0.2 mg/mL

• Buffer:

  PBS with 0.1 mg/ml BSA and 0.05% sodium azide

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.

• Fragment:

  IgG

• Symbol:

  CD3E

• NCBI Official Name:

  CD3e molecule, epsilon (CD3-TCR complex)

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  T-cell surface glycoprotein CD3 epsilon chain, T-cell surface antigen T3/Leu-4 epsilon chain, CD3e, CD3E, T3E

• Tested Applications:

  WB, Flow, IP

• Physical Properties:

  Liquid