CLEC4E Antibody

• Background :

  CLEC4 is a member of the C-type lectin family of proteins that plays a role in inflammatory and immune response. CLEC4E, also called Mincle (Macrophage-inducible C-type lectin), is found on the surface of activated macrophages and phagocytes. It is a receptor for both non-self (fungi and mycobacteria), and self (damaged cells) ligands. Dead cells release SAP130 (Sin3A-Associated Protein, 130kDa), a small nuclear ribonucleoprotein component. CLEC4E senses this and interacts with the ITAM-containing adaptor protein FcRgamma, and via Syk and CARD9 signaling, activates the production of inflammatory cytokines such as TNFa, MIP-2 and IL-6.

• NCBI Gene ID :

  26253

• Swiss Prot :

  Q9ULY5

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  A recombinant protein fragment from the C-terminal portion of human CLEC4E was used as the immunogen for this antibody.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Immunology

• Purification :

  Protein A affinity chromatography

• Concentration :

  0.5 mg/mL

• Buffer :

  PBS with 0.1 mg/ml BSA and 0.05% sodium azide

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Aliquot and Store at -20˚ C. Avoid freez-thaw cycles.

• Fragment :

  IgG

• Symbol :

  CLEC4E

• NCBI Official Name :

  C-type lectin domain family 4 member E

• NCBI Organism :

  Homo sapiens

• Tested Applications :

  WB

• Physical Properties :

  Liquid