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GALNT4 Antibody

CAT: 0223-55-079Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-55-079Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. In vitro, the encoded protein can complement other GalNAc-Ts in the complete O-glycosylation of the mucin-1 tandem repeat and can O-glycosylate the P-selectin glycoprotein ligand-1 molecule. The coding region of this gene is contained within a single exon.
NCBI Gene ID
1005280308693
Swiss Prot
Q8N4A0
Accession Number
Q8N4A0
Host
Rabbit
Reactivity
Human
Immunogen
This GALNT4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 93-120 amino acids from the N-terminal region of human GALNT4.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
67 kDa
Fragment
Rabbit Ig
Symbol
GALNT4
NCBI Official Name
Polypeptide N-acetylgalactosaminyltransferase 4
NCBI Organism
Homo sapiens
Background Reference 01
O'Halloran, A.M., et al. J. Thromb. Thrombolysis 27 (2) :175-184 (2009)
Background Reference 02
Argueso, P., et al. Invest. Ophthalmol. Vis. Sci. 44 (1) :86-92 (2003)
Background Reference 03
Hassan, H., et al. J. Biol. Chem. 275 (49) :38197-38205 (2000)
Background Reference 04
Bennett, E.P., et al. J. Biol. Chem. 273 (46) :30472-30481 (1998)
Other Product Names
Polypeptide N-acetylgalactosaminyltransferase 4, Polypeptide GalNAc transferase 4, GalNAc-T4, pp-GaNTase 4, Protein-UDP acetylgalactosaminyltransferase 4, UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 4, GALNT4
Tested Applications
WB, Flow
Protein ID
338817878
Physical Properties
Liquid

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