IRF8 Antibody

• Background:

  Interferon regulatory factor 8 (IRF8, interferon consensus sequence-binding protein, Ion ChannelSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-. and IFN-.. IRF family proteins also control expression of IFN-. and IFN-.-regulated genes that are induced by viral infection.

• NCBI Gene ID:

  3394

• Swiss Prot:

  Q02556

• Accession Number:

  NP_002154

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat, Dog, Zebrafish

• Immunogen:

  Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human IRF8.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Transcription, Cancer, Signal Transduction, Immunology

• Purification:

  Antibody is purified by peptide affinity chromatography method.

• Positive Control:

  Cat. No. 1211 - HepG2 Cell Lysate

• Concentration:

  Batch dependent

• Buffer:

  Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  For short periods of storage (days) store at 4˚ C. For longer periods of storage, store IRF8 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

• Calculated Molecular Weight:

  48 kDa

• Applications Notes:

  IRF8 antibody can be used for detection of IRF8 by ELISA at 1:62500. IRF8 antibody can be used for detection of IRF8 by western blot at 0.5-2.0 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

• Symbol:

  IRF8

• NCBI Official Name:

  Interferon regulatory factor 8

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Kebin Liu, et al., (2007) Cancer Res 67:3301.

• Other Product Names:

  IRF8, ICSBP, IRF-8, ICSBP1, H-ICSBP

• Tested Applications:

  ELISA, WB, IHC

• Protein ID:

  4504567

• Physical Properties:

  Liquid