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HTR1B Antibody

CAT: 0223-31-114Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0223-31-114Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The pathophysiology of depression remains enigmatic, although abnormalities that involve serotonin signaling have been implicated. The serotonin 1B receptor [5-hydroxytryptamine (5-HT1B) receptor] interacts with p11. p11 increases localization of 5-HT1B receptors at the cell surface. p11 is increased in rodent brains by antidepressants or electroconvulsive therapy, but decreased in an animal model of depression and in brain tissue from depressed patients. Overexpression of p11 increases 5-HT1B receptor function in cells and recapitulates certain behaviors seen after antidepressant treatment in mice. p11 knockout mice exhibit a depression-like phenotype and have reduced responsiveness to 5-HT1B receptor agonists and reduced behavioral reactions to an antidepressant.
NCBI Gene ID
3351
Swiss Prot
P28222
Accession Number
NP_000854
Host
Rabbit
Reactivity
Human
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human HTR1B.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Membrane, Signal Transduction, Immunology
Purification
Antibody is purified by protein A chromatography method.
Positive Control
Cat. No. 1211 - HepG2 Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store HTR1B antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
44 kDa
Applications Notes
HTR1B antibody can be used for detection of HTR1B by ELISA at 1:12500. HTR1B antibody can be used for detection of HTR1B by western blot at 1.25 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
HTR1B
NCBI Official Name
5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
NCBI Organism
Homo sapiens
Background Reference 01
L, et al., (2004) Biol. Psychiatry 55 (3), 225-233.
Other Product Names
HTR1B, S12, 5-HT1B, HTR1D2, HTR1DB, 5-HT1DB
Tested Applications
ELISA, WB
Protein ID
4504533
Physical Properties
Liquid

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