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NEURL2 Antibody

CAT: 0223-30-830Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0223-30-830Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
NEURL2 contains 1 NHR (neuralized homology repeat) domain and 1 SOCS box domain. NEURL2 plays an important role in the process of myofiber differentiation and maturation. NEURL2 is the probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. NEURL2 probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, it controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma.
NCBI Gene ID
140825
Swiss Prot
Q9BR09
Accession Number
NP_542787
Host
Rabbit
Reactivity
Human
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human NEURL2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction, Immunology
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
Cat. No. XBL-10413 - Fetal Skeletal Muscle Tissue Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store NEURL2 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
32 kDa
Applications Notes
NEURL2 antibody can be used for detection of NEURL2 by ELISA at 1:312500. NEURL2 antibody can be used for detection of NEURL2 by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
NEURL2
NCBI Official Name
Neuralized E3 ubiquitin protein ligase 2
NCBI Organism
Homo sapiens
Background Reference 01
Song, R., (2006) J. Biol. Chem. 281 (47), 36391-36400.
Other Product Names
NEURL2, C20orf163, MGC125934, MGC125935, OZZ, Ozz-E3, OZZ-E3
Tested Applications
ELISA, WB
Protein ID
18152787
Physical Properties
Liquid

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