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AOC2 Antibody

CAT: 0223-30-046Size: 100 µLDry Ice: NoHazardous: No
CAT#:0223-30-046Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes and ammonia in the presence of copper and quinone cofactor. The protein contains several conserved motifs including the active site of amine oxidases and the histidine residues that likely bind copper. It may be a critical modulator of signal transmission in retina, possibly by degrading the biogenic amines dopamine, histamine, and putrescine.Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes and ammonia in the presence of copper and quinone cofactor. This gene shows high sequence similarity to copper amine oxidases from various species ranging from bacteria to mammals. The protein contains several conserved motifs including the active site of amine oxidases and the histidine residues that likely bind copper. It may be a critical modulator of signal transmission in retina, possibly by degrading the biogenic amines dopamine, histamine, and putrescine. This gene may be a candidate gene for hereditary ocular diseases. Alternate splicing results in multiple transcript variants.
NCBI Gene ID
314
Swiss Prot
O75106
Accession Number
NP_033720
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human AOC2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Membrane
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
Cat. No. 1205 - Jurkat Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store AOC2 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
84 kDa, 81 kDa
Applications Notes
AOC2 antibody can be used for detection of AOC2 by ELISA at 1:312500. AOC2 antibody can be used for detection of AOC2 by western blot at 1.0 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
AOC2
NCBI Official Name
Amine oxidase, copper containing 2 (retina-specific)
NCBI Organism
Homo sapiens
Background Reference 01
Brandenberger, R., (2004) Nat. Biotechnol. 22 (6), 707-716.
Other Product Names
AOC2, DAO2, RAO
Tested Applications
ELISA, WB
Protein ID
60498984
Physical Properties
Liquid

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