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SLC26A5 Antibody

CAT: 0223-29-962Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0223-29-962Size:100 µL
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Background
SLC26A5 is a member of the SLC26A/SulP transporter family. SLC26A5 is specifically expressed in outer hair cells (OHCs) of the cochlea and is essential in auditory processing. Intracellular anions are thought to act as extrinsic voltage sensors, which bind to this protein and trigger the conformational changes required for rapid length changes in OHCs. Mutations in its gene have been associated with non-syndromic hearing loss.This gene is a member of the SLC26A/SulP transporter family. It encodes a protein that is specifically expressed in outer hair cells (OHCs) of the cochlea and is essential in auditory processing. Intracellular anions are thought to act as extrinsic voltage sensors, which bind to this protein and trigger the conformational changes required for rapid length changes in OHCs. Mutations in this gene have been associated with non-syndromic hearing loss. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
NCBI Gene ID
375611
Swiss Prot
P58743
Accession Number
NP_945350
Host
Rabbit
Reactivity
Human, Mouse, Rat, Dog
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human SLC26A5.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Membrane
Purification
Antibody is purified by protein A chromatography method.
Positive Control
Cat. No. 1211 - HepG2 Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store SLC26A5 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
81 kDa, 75 kDa, 56 kDa
Applications Notes
SLC26A5 antibody can be used for detection of SLC26A5 by ELISA at 1:312500. SLC26A5 antibody can be used for detection of SLC26A5 by western blot at 2.5 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
SLC26A5
NCBI Official Name
Solute carrier family 26 (anion exchanger), member 5
NCBI Organism
Homo sapiens
Background Reference 01
Chambard, J.M. (2005) Pflugers Arch. 450 (1), 34-44.
Other Product Names
SLC26A5, DFNB61, MGC118886, MGC118887, MGC118888, MGC118889, PRES
Tested Applications
ELISA, WB, IHC
Protein ID
39752683
Physical Properties
Liquid

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