STEAP3 Antibody

• Background:

  AS an endosomal ferrireductase, STEAP3 is required for efficient transferrin-dependent iron uptake in erythroid cells. It participates in erythroid iron homeostasis by reducing Fe (3+) to Fe (2+) and can also reduce of Cu (2+) to Cu (1+), suggesting that it participates in copper homeostasis. STEAP3 uses NAD (+) as acceptor (By similarity) . It may play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. STEAP3 is indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCT.

• NCBI Gene ID:

  55240

• Swiss Prot:

  A8K6E3

• Accession Number:

  NP_878919

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human STEAP3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Membrane, Cancer

• Purification:

  Antibody is purified by peptide affinity chromatography method.

• Positive Control:

  Cat. No. XBL-10409 - Fetal Liver Tissue Lysate

• Concentration:

  Batch dependent

• Buffer:

  Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  For short periods of storage (days) store at 4˚ C. For longer periods of storage, store STEAP3 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

• Calculated Molecular Weight:

  56 kDa

• Applications Notes:

  STEAP3 antibody can be used for detection of STEAP3 by ELISA at 1:312500. STEAP3 antibody can be used for detection of STEAP3 by western blot at 0.25 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

• Symbol:

  STEAP3

• NCBI Official Name:

  STEAP family member 3, metalloreductase

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Sendamarai, A.K., (2008) Proc. Natl. Acad. Sci. U.S.A. 105 (21), 7410-7415.

• Other Product Names:

  STEAP3, STMP3, TSAP6, dudlin-2, AHMIO2

• Tested Applications:

  ELISA, WB

• Protein ID:

  56549145

• Physical Properties:

  Liquid