STEAP2 Antibody

• Background:

  STEAP2 Antibody: The six-transmembrane epithelial antigen of prostate 2 (STEAP2) is a member of a family of metalloreductases identified as cell-surface antigens in prostate tissue. Similar to two other members of the STEAP family (STEAP 3 and STEAP4), STEAP2 promotes both iron and copper reduction. STEAP2 expression in transfected cells also correlated with iron or copper uptake, suggesting that the STEAP family of proteins may function to stimulate iron and copper uptake. STEAP2 is widely expressed in many tissues in the plasma membrane, but is most highly expressed in prostate. At least three isoforms of STEAP2 are known to exist.

• NCBI Gene ID:

  261729

• Swiss Prot:

  Q8NFT2

• Accession Number:

  Q8NFT2

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Homeostasis

• Purification:

  STEAP2 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1312 - Human Prostate Tissue Lysate

• Concentration:

  1 mg/mL

• Buffer:

  STEAP2 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  STEAP2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Specificity:

  This STEAP2 antibody does not cross-react with other STEAP proteins.

• Symbol:

  STEAP2

• NCBI Official Name:

  Six transmembrane epithelial antigen of the prostate 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Porkka KP, Helenius MA and Visakorpi T. Cloning and characterization of a novel six-transmembrane protein STEAP2, expressed in normal and malignant prostate. Lab Invest.2002; 82:1573-82.

• Background Reference 02:

  Ohgami RS, Campagna DR, McDonald A, et al. The Steap proteins are metalloreductases. Blood2006; 108:1388-94.

• Background Reference 03:

  Ohgami RS, Campagna DR, Greer EL, et al. Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Nat. Genet.2005; 37:1264-9.

• Other Product Names:

  STEAP2 Antibody: STMP, IPCA1, PUMPCn, STAMP1, PCANAP1, UNQ6507/PRO23203, Metalloreductase STEAP2, Prostate cancer-associated protein 1

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  83286886

• Physical Properties:

  Liquid