DTX2 Antibody

• Background:

  DTX2 is a regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. DTX2 probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context and mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. It also functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.

• NCBI Gene ID:

  113878

• Swiss Prot:

  Q6XM87

• Accession Number:

  NP_001096066

• Host:

  Rabbit

• Reactivity:

  Human, Dog, Zebrafish

• Immunogen:

  Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human DTX2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Apoptosis, Homeostasis

• Purification:

  Antibody is purified by peptide affinity chromatography method.

• Positive Control:

  Cat. No. 1211 - HepG2 Cell Lysate

• Concentration:

  Batch dependent

• Buffer:

  Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  For short periods of storage (days) store at 4˚ C. For longer periods of storage, store DTX2 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

• Calculated Molecular Weight:

  62 kDa, 67 kDa, 67 kDa, 67 kDa, 93 kDa, 26 kDa, 93 kDa, 45 kDa

• Applications Notes:

  DTX2 antibody can be used for detection of DTX2 by ELISA at 1:312500. DTX2 antibody can be used for detection of DTX2 by western blot at 0.25 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

• Symbol:

  DTX2

• NCBI Official Name:

  Deltex 2, E3 ubiquitin ligase

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  DTX2, KIAA1528, MGC71098, RNF58

• Tested Applications:

  ELISA, WB

• Protein ID:

  156564386

• Physical Properties:

  Liquid