DTX4 Antibody

• Background :

  The Deltex 4 E3 ubiquitin ligase (DTX4) is a member of a protein family that is involved in Notch signaling and neurogenesis (1) . Recent studies have shown that DTX4 is also associated with the innate immune response (2) . Following the activation of type I interferon signaling, the Nod-like receptor protein 4 (NLRP4) recruits DTX4 for Lys48-linked polyubiquitination and degradation of the kinase TBK1 (NAK), thereby maintaining immune homeostasis during antiviral innate immunity (2) .

• NCBI Gene ID :

  23220

• Swiss Prot :

  Q9Y2E6

• Accession Number :

  NP_055992

• Host :

  Rabbit

• Reactivity :

  Human

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Neuroscience, Innate Immunity

• Purification :

  DTX4 antibody is affinity chromatography purified via peptide column.

• Positive Control :

  Cat. No. 1201 - HeLa Cell Lysate

• Concentration :

  1 mg/mL

• Buffer :

  DTX4 antibody is supplied in PBS containing 0.02% sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  DTX4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Fragment :

  IgG

• Specificity :

  DTX4 antibody is human and mouse reactive. At least two isoforms of DTX4 are known to exist; this antibody will detect both isoforms. DTX4 antibody is predicted to not cross-react with other DTX protein family members.

• Symbol :

  DTX4

• Positive Control 2 :

  Cat. No. 10-901 - Human Spleen Tissue Slide

• NCBI Official Name :

  Deltex 4, E3 ubiquitin ligase

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Kishi N, Tang Z, Maeda Y, et al. Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis. Int. J. Dev. Neurosci. 2001; 19:21-35.

• Background Reference 02 :

  Cui J, Li Y, Zhu L, et al. NLRP4 negatively regulated type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4. Nat. Immunol. 2012; 13:387-95.

• Other Product Names :

  Deltex 4 E3 ubiquitin ligase, RNF155

• Tested Applications :

  ELISA, WB, IHC-P, IF

• Protein ID :

  148237498

• Physical Properties :

  Liquid