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GAPVD1 Antibody

CAT: 0223-29-751Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0223-29-751Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
GAPVD1 acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. It acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. It is also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. It has GEF activity for Rab5 and GAP activity for Ras.
NCBI Gene ID
26130
Swiss Prot
Q14C86-6
Accession Number
NP_056450
Host
Rabbit
Reactivity
Human, Mouse, Rat, Dog
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human GAPVD1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
Cat. No. 1211 - HepG2 Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store GAPVD1 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
166 kDa
Applications Notes
GAPVD1 antibody can be used for detection of GAPVD1 by ELISA at 1:312500. GAPVD1 antibody can be used for detection of GAPVD1 by western blot at 0.25 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
GAPVD1
NCBI Official Name
GTPase activating protein and VPS9 domains 1
NCBI Organism
Homo sapiens
Background Reference 01
Hunker, C.M., (2006) Biochem. Biophys. Res. Commun. 340 (3), 967-975.
Other Product Names
GAPVD1, DKFZP434C212, KIAA1521, MGC138847, MGC138848, RAP6, GAPEX5, GAPex-5
Tested Applications
ELISA, WB, IHC
Protein ID
51093832
Physical Properties
Liquid

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