CES1 Antibody

• Background :

  CES1 is one of the enzymes responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin. They also hydrolize long-chain fatty acid esters and thioesters. This enzyme is known to hydrolyze aromatic and aliphatic esters and is necessary for cellular cholesterol esterification. It may also play a role in detoxification in the lung and/or protection of the central nervous system from ester or amide compounds. Carboxylesterase deficiency may be associated with non-Hodgkin lymphoma or B-cell lymphocytic leukemia.Carboxylesterase 1 is a member of a large multigene family. The enzymes encoded by these genes are responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin. They also hydrolize long-chain fatty acid esters and thioesters. This enzyme is known to hydrolyze aromatic and aliphatic esters and is necessary for cellular cholesterol esterification. It may also play a role in detoxification in the lung and/or protection of the central nervous system from ester or amide compounds. Carboxylesterase deficiency may be associated with non-Hodgkin lymphoma or B-cell lymphocytic leukemia. Three transcript variants encoding three different isoforms have been found for this gene.

• NCBI Gene ID :

  1066

• Swiss Prot :

  P23141

• Accession Number :

  NP_001020365

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human CES1.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cancer

• Purification :

  Antibody is purified by protein A chromatography method.

• Positive Control :

  PANC1 Cell Lysate

• Concentration :

  Batch dependent

• Buffer :

  Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  For short periods of storage (days) store at 4˚ C. For longer periods of storage, store CES1 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

• Calculated Molecular Weight :

  62 kDa, 63 kDa, 62 kDa, 8 kDa

• Applications Notes :

  CES1 antibody can be used for detection of CES1 by ELISA at 1:312500. CES1 antibody can be used for detection of CES1 by western blot at 1.25 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

• Symbol :

  CES1

• NCBI Official Name :

  Carboxylesterase 1

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Alam, M., (2006) J. Lipid Res. 47 (2), 375-383.

• Other Product Names :

  CES1, CEH, CES2, HMSE, HMSE1, SES1, REH, TGH, ACAT, CE-1, PCE-1, hCE-1

• Tested Applications :

  ELISA, WB

• Protein ID :

  68508965

• Physical Properties :

  Liquid