CYP2E1 Antibody

CYP2E1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer.This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer.

1571

P05181

NP_000764

Human

Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human CYP2E1.

Unconjugated

Primary Antibodies

Membrane, Cancer, Signal Transduction

Antibody is purified by peptide affinity chromatography method.

Cat. No. XBL-10409 - Fetal Liver Tissue Lysate

Batch dependent

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

None

Blue Ice

For short periods of storage (days) store at 4˚ C. For longer periods of storage, store CYP2E1 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

54 kDa

CYP2E1 antibody can be used for detection of CYP2E1 by ELISA at 1:312500. CYP2E1 antibody can be used for detection of CYP2E1 by western blot at 1.0 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

CYP2E1

Cytochrome P450, family 2, subfamily E, polypeptide 1

Homo sapiens

Dey, A., (2006) Arch. Biochem. Biophys. 447 (2), 155-166.

CYP2E1, CPE1, CYP2E, P450-J, P450C2E

ELISA, WB

10834998