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SF3B1 Antibody

CAT: 0223-29-408Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0223-29-408Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
SF3B1 is subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP) . The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures.
NCBI Gene ID
23451
Swiss Prot
O75533
Accession Number
AAH56155
Host
Rabbit
Reactivity
Human, Mouse, Rat, Dog
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human SF3B1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
Antibody is purified by protein A chromatography method.
Positive Control
Cat. No. 1205 - Jurkat Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store SF3B1 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
87 kDa, 146 kDa
Applications Notes
SF3B1 antibody can be used for detection of SF3B1 by ELISA at 1:312500. SF3B1 antibody can be used for detection of SF3B1 by western blot at 0.3125 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
SF3B1
NCBI Official Name
Splicing factor 3b, subunit 1, 155kDa
NCBI Organism
Homo sapiens
Background Reference 01
Strausberg, R.L., Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002) .
Other Product Names
SF3B1, MDS, PRP10, Hsh155, PRPF10, SAP155, SF3b155
Tested Applications
ELISA, WB
Protein ID
33525215
Physical Properties
Liquid

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