Elf3 Antibody

• Background:

  Elf3 is a transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. It acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter (By similarity) . It also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. IT represses KRT4 promoter activity (By similarity) . It may play an important role in epithelial cell differentiation and tumorigenesis and may be a critical downstream effector of the ERBB2 signaling pathway (By similarity) . It may be associated with mammary gland development and involution. It plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development.

• NCBI Gene ID:

  13710

• Swiss Prot:

  Q3UPW2-2

• Accession Number:

  NP_031947

• Host:

  Rabbit

• Reactivity:

  Mouse

• Immunogen:

  Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of mouse Elf3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Transcription

• Purification:

  Antibody is purified by peptide affinity chromatography method.

• Positive Control:

  Cat. No. 1422 - Mouse Trachea Tissue Lysate

• Concentration:

  Batch dependent

• Buffer:

  Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  For short periods of storage (days) store at 4˚ C. For longer periods of storage, store Elf3 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

• Calculated Molecular Weight:

  41 kDa

• Applications Notes:

  Elf3 antibody can be used for detection of Elf3 by ELISA at 1:312500. Elf3 antibody can be used for detection of Elf3 by western blot at 0.25 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

• Symbol:

  Elf3

• NCBI Official Name:

  E74-like factor 3

• NCBI Organism:

  Mus musculus

• Other Product Names:

  Elf3, ESE-1, ESX, jen

• Tested Applications:

  ELISA, WB

• Protein ID:

  6679629

• Physical Properties:

  Liquid