ERCC8 Antibody

• Background :

  ERCC8 is a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS) . This gene encodes a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS) . CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes.

• NCBI Gene ID :

  1161

• Swiss Prot :

  Q13216

• Accession Number :

  NP_000073

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human ERCC8.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Transcription

• Purification :

  Antibody is purified by peptide affinity chromatography method.

• Positive Control :

  Cat. No. XBL-10413 - Fetal Skeletal Muscle Tissue Lysate

• Concentration :

  Batch dependent

• Buffer :

  Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  For short periods of storage (days) store at 4˚ C. For longer periods of storage, store ERCC8 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

• Calculated Molecular Weight :

  44 kDa

• Applications Notes :

  ERCC8 antibody can be used for detection of ERCC8 by ELISA at 1:62500. ERCC8 antibody can be used for detection of ERCC8 by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

• Symbol :

  ERCC8

• NCBI Official Name :

  Excision repair cross-complementing rodent repair deficiency, complementation group 8

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Bethke, L., (2008) J. Natl. Cancer Inst. 100 (4), 270-276.

• Other Product Names :

  ERCC8, CKN1, CSA, UVSS2

• Tested Applications :

  ELISA, WB

• Protein ID :

  4557467

• Physical Properties :

  Liquid