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ERCC8 Antibody

CAT: 0223-27-507Size: 100 µLDry Ice: NoHazardous: No
CAT#:0223-27-507Size:100 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
ERCC8 is a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS) . This gene encodes a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS) . CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes.
NCBI Gene ID
1161
Swiss Prot
Q13216
Accession Number
NP_000073
Host
Rabbit
Reactivity
Human
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human ERCC8.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Transcription
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
Cat. No. XBL-10413 - Fetal Skeletal Muscle Tissue Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store ERCC8 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
44 kDa
Applications Notes
ERCC8 antibody can be used for detection of ERCC8 by ELISA at 1:62500. ERCC8 antibody can be used for detection of ERCC8 by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
ERCC8
NCBI Official Name
Excision repair cross-complementing rodent repair deficiency, complementation group 8
NCBI Organism
Homo sapiens
Background Reference 01
Bethke, L., (2008) J. Natl. Cancer Inst. 100 (4), 270-276.
Other Product Names
ERCC8, CKN1, CSA, UVSS2
Tested Applications
ELISA, WB
Protein ID
4557467
Physical Properties
Liquid

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