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RHOC Antibody

CAT: 0223-27-070Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0223-27-070Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
RHOC Is a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. RHOC is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of RHOC is associated with tumor cell proliferation and metastasis.This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified.
NCBI Gene ID
389
Swiss Prot
P08134
Accession Number
NP_786886
Host
Rabbit
Reactivity
Human, Mouse, Rat, Dog, C. elegans, Drosophila
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human RHOC.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction, Immunology
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
Cat. No. XBL-10409 - Fetal Liver Tissue Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store RHOC antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
22 kDa
Applications Notes
RHOC antibody can be used for detection of RHOC by ELISA at 1:62500. RHOC antibody can be used for detection of RHOC by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
RHOC
NCBI Official Name
Ras homolog family member C
NCBI Organism
Homo sapiens
Background Reference 01
Sousa, J.F. (er) BMC Cancer 8, 19 (2008) .
Other Product Names
RHOC, ARH9, ARHC, H9, MGC1448, MGC61427, RHOH9
Tested Applications
ELISA, WB
Protein ID
28395033
Physical Properties
Liquid

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