FOLH1 Antibody

FOLH1 is a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. A mutation in the gene encoding FOLH1 may be associated with impaired intestinal absorption of dietary folates.It is used as an effective diagnostic and prognostic indicator of prostate cancer.This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants.

2346

Q04609

NP_004467

Human, Mouse, Rat

Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human FOLH1.

Unconjugated

Primary Antibodies

Membrane, Cancer, Signal Transduction

Antibody is purified by peptide affinity chromatography method.

Cat. No. 1309 - Human Placenta Lysate

Batch dependent

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

None

Blue Ice

For short periods of storage (days) store at 4˚ C. For longer periods of storage, store FOLH1 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

84 kDa

FOLH1 antibody can be used for detection of FOLH1 by ELISA at 1:312500. FOLH1 antibody can be used for detection of FOLH1 by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

FOLH1

Folate hydrolase (prostate-specific membrane antigen) 1

Homo sapiens

Huemer, M., (2008) Mol. Genet. Metab. 94 (1), 46-51.

FOLH1, FGCP, FOLH, GCP2, GCPII, NAALAD1, NAALAdase, PSM, PSMA, mGCP

ELISA, WB

4758398