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KCNN1 Antibody

CAT: 0223-28-240Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0223-28-240Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. KCNN1 is a member of the KCNN family of potassium channels.
NCBI Gene ID
3780
Swiss Prot
Q6DJU4
Accession Number
NP_002239
Host
Rabbit
Reactivity
Human
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human KCNN1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Membrane
Purification
Antibody is purified by protein A chromatography method.
Positive Control
Cat. No. 1205 - Jurkat Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store KCNN1 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
60 kDa
Applications Notes
KCNN1 antibody can be used for detection of KCNN1 by ELISA at 1:312500. KCNN1 antibody can be used for detection of KCNN1 by western blot at 1.25 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
KCNN1
NCBI Official Name
Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1
NCBI Organism
Homo sapiens
Background Reference 01
Arnold, S.J., et al., (2003) Neuroreport 14 (2), 191-195.
Other Product Names
KCNN1, SK1, hSK1, SKCA1, KCa2.1
Tested Applications
ELISA, WB
Protein ID
25777643
Physical Properties
Liquid

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