CACNB4 Antibody

CAT: 0223-23-838Size: 100 µLDry Ice: NoHazardous: No
CAT#:0223-23-838Size:100 µL
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Background
This gene encodes a member of the beta subunit family of voltage-dependent calcium channel complex proteins. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein encoded by this locus plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE) and juvenile myoclonic epilepsy (JME) . Multiple transcript variants encoding different isoforms have been found for this gene.
NCBI Gene ID
785
Swiss Prot
O00305
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 401-520 of human CACNB4 (NP_000717.2) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience, Signal Transduction
Purification
Affinity purification
Positive Control
Mouse brain
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 58kDa
Fragment
IgG
Applications Notes
WB: 1:1000 - 1:2000
Symbol
CACNB4
Positive Control 2
Rat brain
NCBI Official Name
Calcium channel, voltage-dependent, beta 4 subunit
NCBI Organism
Homo sapiens
Other Product Names
CACNB4, CAB4, CACNLB4, EA5, EJM, EIG9, EJM4, EJM6
Tested Applications
WB
Physical Properties
Liquid

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