DPM1 Antibody

• Background :

  Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER) . Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. Human DPM1 lacks a carboxy-terminal transmembrane domain and signal sequence and is regulated by DPM2. Mutations in this gene are associated with congenital disorder of glycosylation type Ie. Alternative splicing results in multiple transcript variants.

• NCBI Gene ID :

  8813

• Swiss Prot :

  O60762

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human DPM1 (NP_003850.1) .

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Other

• Purification :

  Affinity purification

• Positive Control :

  NCI-H460

• Concentration :

  Batch dependent

• Buffer :

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  Observed: 30kDa

• Fragment :

  IgG

• Symbol :

  DPM1

• Positive Control 2 :

  HeLa

• Positive Control 3 :

  SKOV3

• Positive Control 4 :

  Mouse pancreas

• Positive Control 5 :

  Mouse liver

• Positive Control 6 :

  Mouse kidney

• NCBI Official Name :

  Dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit

• NCBI Organism :

  Homo sapiens

• Other Product Names :

  DPM1, dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit, CDGIE, MPDS, dolichol monophosphate mannose synthase

• Tested Applications :

  WB, IF

• Physical Properties :

  Liquid