PRKCE Antibody

• Background:

  Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS) -mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior.

• NCBI Gene ID:

  5581

• Swiss Prot:

  Q02156

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 488-737 of human PRKCE (NP_005391.1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Apoptosis, Cell Cycle, Immunology, Signal Transduction

• Purification:

  Affinity purification

• Positive Control:

  293T

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 100kDa

• Fragment:

  IgG

• Symbol:

  PRKCE

• Positive Control 2:

  HT-29

• Positive Control 3:

  Mouse brain

• Positive Control 4:

  Mouse lung

• NCBI Official Name:

  Protein kinase C epsilon type

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Protein kinase C epsilon type, nPKC-epsilon, PRKCE, PKCE

• Tested Applications:

  WB, IHC

• Physical Properties:

  Liquid