E2F1 Antibody

CAT: 0223-18-476Size: 100 µLDry Ice: NoHazardous: No
CAT#:0223-18-476Size:100 µL
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Background
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.
NCBI Gene ID
1869
Swiss Prot
Q01094
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide of human E2F1
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Cancer, Cell Cycle, Signal Transduction, Transcription
Purification
Affinity purification
Positive Control
A-431
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 70kDa
Fragment
IgG
Symbol
E2F1
Positive Control 2
BxPC-3
Positive Control 3
U-87MG
Positive Control 4
NIH/3T3
NCBI Official Name
E2F transcription factor 1
NCBI Organism
Homo sapiens
Other Product Names
E2F1, E2F-1, RBBP3, RBP3, RBAP1
Tested Applications
WB, IF
Physical Properties
Liquid

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