E2F1 Antibody
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- Dry Ice Shipment: No
E2F1 Antibody
Background :
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.NCBI Gene ID :
1869Swiss Prot :
Q01094Host :
RabbitReactivity :
Human, Mouse, RatImmunogen :
A synthetic peptide of human E2F1Clonality :
PolyclonalConjugation :
UnconjugatedType :
Primary AntibodiesField of Research :
Apoptosis, Cancer, Cell Cycle, Signal Transduction, TranscriptionPurification :
Affinity purificationPositive Control :
A-431Concentration :
Batch dependentBuffer :
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.Modification :
NoneShipping Conditions :
Blue IceStorage Conditions :
Store at -20˚ C. Avoid freeze / thaw cycles.Calculated Molecular Weight :
Observed: 70kDaFragment :
IgGSymbol :
E2F1Positive Control 2 :
BxPC-3Positive Control 3 :
U-87MGPositive Control 4 :
NIH/3T3NCBI Official Name :
E2F transcription factor 1NCBI Organism :
Homo sapiensOther Product Names :
E2F1, E2F-1, RBBP3, RBP3, RBAP1Tested Applications :
WB, IFPhysical Properties :
Liquid
