GPX1 Antibody

• Background:

  This gene encodes a member of the glutathione peroxidase family. Glutathione peroxidase functions in the detoxification of hydrogen peroxide, and is one of the most important antioxidant enzymes in humans. This protein is one of only a few proteins known in higher vertebrates to contain selenocysteine, which occurs at the active site of glutathione peroxidase and is coded by UGA, that normally functions as a translation termination codon. In addition, this protein is characterized in a polyalanine sequence polymorphism in the N-terminal region, which includes three alleles with five, six or seven alanine (ALA) repeats in this sequence. The allele with five ALA repeats is significantly associated with breast cancer risk. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

• NCBI Gene ID:

  2876

• Swiss Prot:

  P07203

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 50-203 of human GPX1 (NP_000572.2) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Apoptosis, Cancer, Cell Cycle, Neuroscience, Signal Transduction

• Purification:

  Affinity purification

• Positive Control:

  293T

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 22kDa

• Fragment:

  IgG

• Symbol:

  GPX1

• Positive Control 2:

  Mouse liver

• Positive Control 3:

  Mouse kidney

• Positive Control 4:

  Rat liver

• Positive Control 5:

  Rat spleen

• NCBI Official Name:

  Glutathione peroxidase 1

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Glutathione Peroxidase 1; GSHPx-1; Cellular Glutathione Peroxidase

• Tested Applications:

  WB, IF

• Physical Properties:

  Liquid