PCBP1 Antibody

• Background:

  This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly (rC) -binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.

• NCBI Gene ID:

  5093

• Swiss Prot:

  Q15365

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  A synthetic peptide corresponding to a sequence within amino acids 100-200 of human PCBP1 (NP_006187.2) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  Affinity purification

• Positive Control:

  NIH/3T3

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 37kDa

• Fragment:

  IgG

• Symbol:

  PCBP1

• Positive Control 2:

  HepG2

• Positive Control 3:

  MCF7

• Positive Control 4:

  Mouse liver

• Positive Control 5:

  Rat liver

• NCBI Official Name:

  Poly (rC) binding protein 1

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  PCBP1, HNRPX, HNRPE1, hnRNP-X, HEL-S-85, hnRNP-E1

• Tested Applications:

  WB, IHC, IF

• Physical Properties:

  Liquid