SARS-CoV-2 RBD Potent Neutralizing Antibody, monoclonal, Chimeric

• Background:

  It's been reported that Coronavirus can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.

• NCBI Gene ID:

  43740568

• Swiss Prot:

  P0DTC2

• Reactivity:

  Mouse

• Immunogen:

  Anti-SARS-CoV-2 RBD Potent Neutralizing Antibody, Chimeric mAb, Human IgG1 (AM128) is a chimeric monoclonal antibody combining the constant domains of the human IgG1 molecule with mouse variable regions. Pseudovirus assay shows that this antibody has potent neutralizing activity against pseudovirus bearing SARS-CoV-2 Spike protein.

• Clonality:

  Recombinant Monoclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Infectious Disease, COVID-19

• Purification:

  >95% as determined by SDS-PAGE.

• Concentration:

  Batch dependent

• Buffer:

  Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 . Normally trehalose is added as protectant before lyophilization.

• Modification:

  None

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  For long term storage, the product should be stored at lyophilized state at -20˚ C or lower..Please avoid repeated freeze-thaw cycles.This product is stable after storage at:.-20 to -70˚ C for 12 months in lyophilized state from date of receipt; .-70˚ C for 3 months under sterile conditions after reconstitution.

• Fragment:

  Human IgG1/kappa

• Specificity:

  This product is a specific antibody against SARS-CoV-2 Spike protein RBD domain. No cross-reactivity is detected with Spike protein RBD domain of other coronaviruses, including SARS-CoV, MERS-CoV, HCoV-229E, HCoV-NL63, HCoV-OC43 and HCoV-HKU1.

• Symbol:

  S

• NCBI Official Name:

  Surface glycoprotein

• NCBI Organism:

  SARS-CoV-2

• Other Product Names:

  Spike glycoprotein

• Tested Applications:

  ELISA, WB

• Physical Properties:

  Lyophilized