Anti-SARS-CoV-2 RBD Potent Neutralizing Antibody, Human IgG1 (AM180)
CAT:
716-SPD-M180-1mg
Size:
1 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No




Anti-SARS-CoV-2 RBD Potent Neutralizing Antibody, Human IgG1 (AM180)
- Background: It's been reported that Coronavirus can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
- Description: Anti-SARS-CoV-2 RBD Potent Neutralizing Antibody, Human IgG1 (AM180) is isolated from a SARS-CoV-2 infected patient and is recombinantly produced from human 293 cells (HEK293). This antibody recognizes the SARS-CoV-2 Spike Protein RBD domain and inhibits the interaction between SARS-CoV-2 RBD and ACE2 with an IC50 of 0.98 μg/mL using SARS-CoV-2 Inhibitor Screening Kit.Pseudovirus assay shows that this antibody has potent neutralizing activity against pseudovirus bearing SARS-CoV-2 Spike protein.
- Host: HEK 293
- Origin Species: Human
- Target: Spike RBD
- Conjugation: Unconjugated
- Tag: Human IgG1 | Human Kappa
- Stability: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower._x000D_Please avoid repeated freeze-thaw cycles.
- Purity: 95%
- Bioactivity: Serial dilutions of Anti-SARS-CoV-2 RBD Potent Neutralizing Antibody, Human IgG1 (AM180) (Cat. No. SPD-M180) were added into SARS-CoV-2 S protein RBD, His Tag (Cat. No. SPD-C52H3): Biotinylated Human ACE2, His,Avitag (Cat. No. AC2-H82E6) binding reactions. The half maximal inhibitory concentration (IC50) is 0.98269 μg/mL (Routinely tested).
- Format: Powder
- Buffer: PBS, pH7.4
- Additives: Trehalose
- Shipping Conditions: Room Temperature
- Storage Conditions: -20°C