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TRIM58 Antibody

CAT: 0223-8545-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-8545-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
TRIM58 Antibody: TRIM58 is a member of the tripartite motif-containing family of proteins that frequently possess E3 ubiquitin ligase activities (1) . TRIM58 is strongly expressed in erythroid lineage cells and is further upregulated during late erythroid maturation. Recent experiments suggest that TRIM58 facilitates erythroblast enucleation by ubiquitinating the intermediate chain of the microtubule motor dynein, thereby inducing proteolytic degradation (2) .
NCBI Gene ID
25893
Swiss Prot
Q8NG06
Accession Number
NP_056246
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
TRIM58 antibody was raised against a peptide corresponding to 17 amino acids near the carboxy terminus of human TRIM58.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell
Purification
TRIM58 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1301 - Human Heart Tissue Lysate
Concentration
1 mg/mL
Buffer
TRIM58 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
TRIM58 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
TRIM58
Positive Control 2
Cat. No. 1405 - Mouse Kidney Tissue Lysate
NCBI Official Name
Tripartite motif containing 58
NCBI Organism
Homo sapiens
Background Reference 01
Napolitano LM and Meroni G. TRIM family: Pleiotropy and diversification through homomultimer and heteromultimer formation. IUBMB Life 2012; 64:64-71.
Background Reference 02
Thom CS, Traxler EA, Khandros E, et al. Trim58 degrades dynein and regulates terminal erythropoiesis. Dev. Cell 2014; 30:688-700.
Other Product Names
TRIM58 Antibody: Tripartite motif containing 58 protein, BIA2
Tested Applications
ELISA, WB
Protein ID
112421127
Physical Properties
Liquid

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