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SOX10 Antibody

CAT: 0223-8481-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-8481-01Size:0.02 mg
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Background
SOX10 Antibody: SOX10 is a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and the determination of the cell fate (1) . The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins (2) . This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development (2) . Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschprung disease (3) . SLC30A8 expression in beta-cells was found to be influenced by cytokine expression, particularly IFN-gamma and IL-1beta (4) .
NCBI Gene ID
6663
Swiss Prot
P56693
Accession Number
NP_008872
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
SOX10 antibody was raised against a peptide corresponding to 18 amino acids near the amino terminus of human SOX10.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction, Stem Cell
Purification
SOX10 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1461 - Rat Heart Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Pig: (100%), Chicken: (89%), Goat: (100%)
Buffer
SOX10 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
SOX10 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
SOX10 Antibody is predicted to not cross-react with other SOX familiy members.
Symbol
SOX10
NCBI Official Name
SRY-box 10
NCBI Organism
Homo sapiens
Background Reference 01
Pusch C, Hustert E, Pfeifer D, et al. The SOX10/Sox10 gene from human and mouse: sequence, expression, and transactivation by the encoded HMG domain transcription factor. Hum. Genet. 1998; 103:115-23.
Background Reference 02
Rehberg S, Lischka P, Glaser G, et al. Sox10 is an active nucleocytoplasmic shuttle protein, and shuttling is crucial for Sox10-mediated transactivation. Mol. Cell Biol. 2002; 22:5826-34.
Background Reference 03
Pingault V, Bondurand N, Kuhlbrodt K, et al. SOX10 mutations in patients with Waardenburg-Hirschprung disease. Nat. Genet. 1998; 18:171-3.
Other Product Names
SOX10 Antibody: SRY (sex determining region Y) -box 10, DOM, WS4, PCWH, WS2E, WS4C
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
5902104
Physical Properties
Liquid

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