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SOX18 Antibody

CAT: 0223-7919-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7919-01Size:0.02 mg
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Background
SOX18 is a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate (1,2) . SOX18 is part of the SoxF subgroup which plays an important role in the differentiation of different cell types (3) . SOX is known to be involved with vascularization and endothelial development, suggesting that it may be useful as a potential target for inhibiting tumor angiogenesis (4) . Mutations in this gene have been associated with recessive and dominant forms of hypotrichosis-lymphedema-telangiectasia (5) .
NCBI Gene ID
54345
Swiss Prot
P35713
Accession Number
NP_060889
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell
Purification
SOX18 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1212 - 3T3 Cell Lysate
Concentration
1 mg/mL
Buffer
SOX18 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
SOX18 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
SOX18 antibody is human, mouse and rat reactive. SOX18 is predicted to not cross-react with other SOX proteins.
Symbol
SOX18
NCBI Official Name
RY (sex determining region Y) -box 18
NCBI Organism
Homo sapiens
Background Reference 01
Dunn TL, Mynett-Johnson L, Wright EM, et al. Sequence and expression of Sox-18 encoding another HMG-box transcription factor. Gene 1995; 161:223-5.
Background Reference 02
Jiang T, Hou CC, She ZY, et al. The SOX gene family: function and regulation in testis determination and male fertility maintenance. Mol. Biol. Rep. 2013; 40:2187-94.
Background Reference 03
Francois M, Koopman P, and Beltrame M. SoxF genes: key players in the development of the cardiovascular system. Int. J. Biochem. Cell Biol. 2010; 42:445-8.
Background Reference 04
Young N, Hahn CN, Poh A, et al. Effect of disrupted SOX18 transcription factor function on tumor growth, vascularization, and endothelial development. J. Natl. Cancer Inst. 2006; 98:1060-7.
Other Product Names
SOX18 Antibody: HLTS, Transcription factor SOX-18
Tested Applications
ELISA, WB
Protein ID
8924248
Physical Properties
Liquid

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