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IL-11 Antibody

CAT: 0223-8453-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-8453-01Size:0.02 mg
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Background
Interleukin 11 is a pleiotropic cytokine that has multiple effects on both hematopoietic and nonhematopoietic cells. Many of the biological effects described for IL-11 overlap those for IL-6 (1) . It directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (2) . IL-11 promotes the proliferation of hepatocytes in response to liver damage. IL-11 binds to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 (3) . Clinically it is used to prevent severe thrombocytopenia and the reduction of the need for platelet transfusion following myelo-suppressive chemotherapy (4) .
NCBI Gene ID
3589
Swiss Prot
P20809
Accession Number
NP_000632
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell, Immunology
Purification
IL-11 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1201 - HeLa Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Rat: (94%), Mouse: (88%)
Buffer
IL-11 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
IL-11 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
IL-11 antibody is human specific. At least two isoforms of IL-11 are known to exist; this antibody will only detect the longest isoform of IL-11.
Symbol
IL-11
Positive Control 2
Cat. No. 17-001 - HeLa Cell Slide
NCBI Official Name
Interleukin 11
NCBI Organism
Homo sapiens
Background Reference 01
Paul SR, Bennett F, Calvetti JA. Molecular cloning of a cDNA encoding interleukin-11, astromal cell-derived lymphopoietic and hematopoietic cytokine. Proc. Natl. Acad. Sci. USA 1990; 87:7512-6.
Background Reference 02
Yang YC and Yin T. Interleukin (IL) -11 mediated signal transduction. Ann. N.Y. Acad. Sci. 1995; 762:31-40.
Background Reference 03
Dimitriadis E, Robb L, Salamonsen LA. Interleukin 11 advances progesterone-induced decidualization of human endometrial stromal cells. Mol. Hum. Reprod. 2002; 8:636-43.
Background Reference 04
Andersson By U, Tani E, Andersson U. Tumor necrosis factor, interleukin 11, and leukemia inhibitory factor produced by Langerhans cells in Langerhans cell histiocytosis. J. Pediatr. Hematol. Oncol. 2004; 26:706-11.
Other Product Names
Interleukin-11, Adipogenesis inhibitory factor, AGIF
Tested Applications
ELISA, WB, ICC, IF
Protein ID
10834994
Physical Properties
Liquid

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