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GAS6 Antibody

CAT: 0223-8365-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-8365-01Size:0.02 mg
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Background
The growth arrest-specific 6 (GAS6) protein is a gamma-carboxyglutamic acid (Gla) -containing protein and a member of a family of plasma vitamin K-dependent proteins. GAS6 is involved in vascular homeostasis, cell proliferation, apoptosis, leukocyte migration, and platelet aggregation (1,2) . GAS6 is the ligand for the type I transmembrane receptor tyrosine kinase receptors Tyro3, Axl, and Mer (3) . This gene is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker (4) . Elevated protein levels are additionally associated with a variety of disease states, including venous thromboembolic disease, systemic lupus erythematosus, chronic renal failure, and preeclampsia (2) .
NCBI Gene ID
2621
Swiss Prot
Q14393
Accession Number
NP_000811
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Homeostasis
Purification
GAS6 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1401 - Mouse Heart Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Rabbit: (95%)
Buffer
GAS6 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
GAS6 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
GAS6 antibody is human, mouse and rat reactive. At least four isoforms of GAS6 are known to exist; this antibody will only detect the longest isoform.
Symbol
GAS6
NCBI Official Name
Growth arrest-specific 6
NCBI Organism
Homo sapiens
Background Reference 01
Schneider C, King RM, and Philipson L. Genes specifically expressed at growth arrest of mammalian cells. Cell 1988; 54:787-93.
Background Reference 02
Laurance S, Lemarie CA, and Blostein MD. Growth arrest-specific gene 6 (gas6) and vascular hemostasis. Adv. Nutr. 2012; 3:196-203.
Background Reference 03
Stitt TN, Conn G, Gore M, et al. The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases. Cell 1995; 80:661-70.
Background Reference 04
Van der Meer JH, van der Poll T, and van ‘t Veer C. TAM receptors, Gas6, and protein S: roles in inflammation and hemostasis. Blood 2014; 123:2460-9.
Other Product Names
Growth arrest-specific 6 protein, AXSF, AXLLG
Tested Applications
ELISA, WB, IHC-P
Protein ID
4557617
Physical Properties
Liquid

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