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TNFAIP1 Antibody

CAT: 0223-8345-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-8345-01Size:0.02 mg
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Background
TNFAIP1 is a BTB/POZ domain-containing protein that belongs to the KCTD10/BACURD family which mediates POZ-POZ interactions and chromatin modeling (1,2) . The expression of TNFAIP1 is developmentally regulated in a tissue-specific manner and can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells (3) . TNFAIP1 may be involved in DNA repair, DNA synthesis, and cell apoptosis. TNFAIP1 is suggested to play a role in the process of cancer and in the innate immunity against the Hepatitis B virus (4,5) .
NCBI Gene ID
7126
Swiss Prot
Q13829
Accession Number
NP_066960
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Cancer, Innate Immunity
Purification
TNFAIP1 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1403 - Mouse Brain Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Chicken: (100%)
Buffer
TNFAIP1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
TNFAIP1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
TNFAIP1 antibody is human, mouse and rat reactive. TNFAIP1 antibody is predicted to not cross-react with other TNFAIP proteins.
Symbol
TNFAIP1
NCBI Official Name
Tumor necrosis factor, alpha-induced protein 1 (endothelial)
NCBI Organism
Homo sapiens
Background Reference 01
Liu M, Sun Z, Zhou A, et al. Functional characterization of the promoter region of human TNFAIP1 gene. Mol. Biol. Rep. 2010; 37:1699-705.
Background Reference 02
Hu X, Yan F, Wang F, et al. TNFAIP1 interacts with KCTD10 to promote the degradation of KCTD10 proteins and inhibit the transcriptional activities of NF-?B and AP-1. Mol. Biol. Rep. 2012; 39:9911-9.
Background Reference 03
Zhang CL, Wang C, Yan WJ, et al. Knockdown of TNFAIP1 inhibits growth and induces apoptosis in osteosarcoma cells through inhibition of the nuclear factor-?B pathway. Oncol. Rep. 2014; 32:1149-55.
Background Reference 04
Kim DM, Chung KS, Choi SJ, et al. RhoB induces apoptosis via direct interaction with TNFAIP1 in HeLa cells. Int. J. Cancer 2009; 125:2520-7.
Other Product Names
Tumor necrosis factor, alpha-induced protein 1, BTB/POZ domain-containing protein TNFAIP1, BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2, BACURD2, EDP1
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
10863937
Physical Properties
Liquid

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