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SLCO1B1 Antibody

CAT: 0223-8197-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-8197-01Size:0.02 mg
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Background
SLCO1B1 is a transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including bilirubin, 17-beta-glucuronosyl estradiol and may play an important role in the clearance of bile acids and organic anions from the liver (1,2) . It contains one Kazal-like domain and belongs to the organo-anion transporter family (2,3) . SLCO1B1 is highly expressed in liver and is localized to the basolateral hepatocyte membrane. It is responsible for the hepatic uptake of the liver-specific hydroxymethylglutaryl-CoA reductase inhibitor in mouse, rat and human (3,4) .
NCBI Gene ID
10599
Swiss Prot
Q9Y6L6
Accession Number
NP_006437
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Homeostasis
Purification
SLCO1B1 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1304 - Human Liver Tissue Lysate
Concentration
1 mg/mL
Buffer
SLCO1B1 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
SLCO1B1 antibody can be stored at 4˚ C, stable for up to one year.
Fragment
IgG
Specificity
SLCO1B1 antibody is human specific. At least four isoforms of SLCO1B1 are known to exist. This antibody is predicted to not cross-react with other SLCO1B proteins.
Symbol
SLCO1B1
Positive Control 2
Cat. No. 10-201 - Human Liver Tissue Slide
NCBI Official Name
Solute carrier organic anion transporter family, member 1B1
NCBI Organism
Homo sapiens
Background Reference 01
Abe T, Kakyo M, Tokui T, et al. Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1. J. Biol. Chem. 1999; 274:17159-63.
Background Reference 02
Konig J, Cui Y, Nies AT, et al. A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane. Am. J. Physiol. Gastrointest. Liver Physiol. 2000; 278:G156-64.
Background Reference 03
Michalski C, Cui Y, Nies AT, et al. A naturally occurring mutation in the SLC21A6 gene causing impaired membrane localization of the hepatocyte uptake transporter. J. Biol. Chem. 2002; 277:43058-63.
Background Reference 04
Yao J, Hong W, Huang J, et al. N-Glycosylation dictates proper processing of organic anion transporting polypeptide 1B1. PLoS One 2012; 7:e52563.
Other Product Names
Solute carrier organic anion transporter family member 1B1, LST1, Solute carrier family 21 member 6, SLC21A6, Sodium-independent organic anion-transporting polypeptide 2, OATP1B1, OATP2, OATPC, Solute carrier family 21 member 6
Tested Applications
ELISA, WB, ICC, IF
Protein ID
225543525
Physical Properties
Liquid

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