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DNAJC13 Antibody

CAT: 0223-8109-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-8109-01Size:0.02 mg
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Background
DNAJC13, also known as receptor-mediated endocytosis 8 (RME8), is the human homolog to a DnaJ domain-containing protein originally identified in a screen for endocytic defects in C. elegans (1) . It is thought to be a co-chaperone of Hsc70 which regulates protein conformation at membrane sites and plays a role in intracellular trafficking, co-localizing with markers of the endosomal system. Recent experiments have indicated that the DNAJC13 protein is involved in membrane trafficking through early endosomes but not through degradative organelles (2) . DNAJC13 has been also been shown to regulate the intracellular trafficking of the epidermal growth factor receptor (3) .
NCBI Gene ID
23317
Swiss Prot
O75165
Accession Number
NP_056083
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Homeostasis
Purification
DNAJC13 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1411 - Mouse Colon Tissue Lysate
Concentration
1 mg/mL
Buffer
DNAJC13 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
DNAJC13 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
DNAJC13 antibody is human and mouse reactive. At least two siforms of DNAJC13 are known to exist; this antibody will detect both isoforms. DNAJC13 antibody is predicted to not cross-react with other DNAJC family members.
Symbol
DNAJC13
Positive Control 2
Cat. No. 10-501 - Human Heart Tissue Slide
Positive Control 3
Cat. No. 1212 - 3T3 Cell Lysate
NCBI Official Name
DnaJ (Hsp40) homolog, subfamily C, member 13
NCBI Organism
Homo sapiens
Background Reference 01
Girard M, Poupon V, Blondeau F, et al. The DnaJ-domain protein RME-8 functions in endosomal trafficking. J. Biol. Chem. 2005; 280:40135-43.
Background Reference 02
Fujibayashi A, Taguchi T, Misaki R, et al. Human RME-8 is involved in membrane trafficking through early endosomes. Cell Struct. Funct. 2008; 33:35-50.
Background Reference 03
Girard M and McPherson PS. RME-8 regulates trafficking of the epidermal growth factor receptor. FEBS Lett. 2008; 582:961-6.
Other Product Names
DNAJ homolog subfamily C member 13, receptor-mediated endocytosis 8, RME8
Tested Applications
ELISA, WB, IHC-P
Protein ID
112421122
Physical Properties
Liquid

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