GLIS2 Antibody

• Background:

  GLIS2, also known as neuronal Krueppel-like, is a 524 amino acid protein that belongs to the GLI C2H2-type zinc-finger protein family (1) . GLIS2 can act either as a transcription repressor or as a transcription activator and may be involved in neuron differentiation (1,2) . GLIS2 is expressed at high levels in kidney and at low levels in heart, lung and placenta. Mutations of GLIS2 have been suggested to be associated with development of progressive chronic kidney disease with characteristics resembling nephronophthisis (3,4) .

• NCBI Gene ID:

  84662

• Swiss Prot:

  Q9BZE0

• Accession Number:

  NP_115964

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Stem Cell, Neuroscience

• Purification:

  GLIS2 antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1204 - K562 Cell Lysate

• Concentration:

  1 mg/mL

• Buffer:

  GLIS2 antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  GLIS2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Fragment:

  IgG

• Specificity:

  GLIS2 antibody is human, mouse and rat reactive.

• Symbol:

  GLIS2

• NCBI Official Name:

  GLIS family zinc finger 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Vasanth S, ZeRuth G, Kang HS, et al. Identification of nuclear localization, DNA binding, and transactivating mechanisms of Kruppel-like zinc finger protein Gli-similar 2 (Glis2) . J. Biol. Chem. 2011; 286:4749-59.

• Background Reference 02:

  Hosking CR, Ulloa F, Hogan C, et al. The transcriptional repressor Glis2 is a novel binding partner for p120 catenin. Mol. Biol. Cell 2007; 18:1918-27.

• Background Reference 03:

  Kim YS, Kang HS, Herbert R, et al. Kruppel-like zinc finger protein Glis2 is essential for the maintenance of normal renal functions. Mol. Cell Biol. 2008; 28:2358-67.

• Background Reference 04:

  Attanasio M, Uhlenhaut NH, Sousa VH, et al. Loss of GLIS2 causes nephronophthisis in humans and mice by increased apoptosis and fibrosis. Nat. Genet. 2007; 39:1018-24.

• Other Product Names:

  GLIS family zinc finger 2, GLI-similar 2, neuronal krueppel-like protein, NKL, NPHP7

• Tested Applications:

  ELISA, WB, IHC-P

• Protein ID:

  110431364

• Physical Properties:

  Liquid