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FOXG1 Antibody

CAT: 0223-8089-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-8089-01Size:0.02 mg
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Background
FOXG1 belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain and plays an important role in the development of the brain and telencephalon (1) . It is essential for the proliferation of progenitor cells in the cerebral cortex and influences regional patterning in the mammalian telencephalon (2,3) . Expression is restricted to the neurons of the developing telencephalon (3) . The loss of FOXG1 results in an accelerated rate of neuronal differentiation and the shortening of the neurogenetic period in the embryonic cerebral cortex (2,4) .
NCBI Gene ID
2290
Swiss Prot
P55316
Accession Number
NP_005240
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience, Stem Cell
Purification
FOXG1 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1463 - Rat Brain Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Chicken: (100%)
Buffer
FOXG1 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
FOXG1 antibody can be stored at 4˚ C, stable for up to one year.
Fragment
IgG
Specificity
FOXG1 antibody is human, mouse and rat reactive.
Symbol
FOXG1
NCBI Official Name
Forkhead box G1
NCBI Organism
Homo sapiens
Background Reference 01
Murphy DB, Wiese S, Burfeind P, et al. Human brain factor 1, a new member of the fork head gene family. Genomics 1994; 21:551-7.
Background Reference 02
Kumamoto T, Toma K, Gunadi, et al. Foxg1 coordinates the switch from nonradially to radially migrating glutamatergic subtypes in the neocortex through spatiotemporal repression. Cell Rep. 2013; 3:931-45.
Background Reference 03
Miyoshi G and Fishell G. Dynamic FoxG1 expression coordinates the integration of multipolar pyramidal neuron precursors into the cortical plate. Neuron 2012;74:1045-58.
Background Reference 04
Mencarelli MA, Spanhol-Rosseto A, Artuso R, et al. Novel FOXG1 mutations associated with the congenital variant of Rett syndrome. J. Med. Genet. 2010; 47:49-53.
Other Product Names
Forkhead box G1, Brain factor 1, Brain factor 2, BF1, BF2, FKH2, FKHL1, FKHL2, FKHL3, FKHL4, Forkhead box protein G1, FOXG1A, FOXG1B, FOXG1C, HBF-1, HBF2, HBF-3, HBF-G2, HFK1, HFK2, HFK3, KHL2, QIN
Tested Applications
ELISA, WB, IF
Protein ID
32307177
Physical Properties
Liquid

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