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HES5 Antibody

CAT: 0223-8055-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-8055-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
HES5 is a member of the HES family of transcriptional repressors, which are the mammalian homologs of the Drosophila Hairy and Enhancer of Split and contain basic Helix-loop-helix (bHLH) and Orange domains (1) . The HES5 gene is a downstream target of the Notch signaling pathway and its expression is downregulated during human cartilage differentiation (2) . HES5 can directly repress transcription of the E3 ligase FBW7-beta, creating a feedback loop that modulates Notch-mediated intestinal and neural stem cell fate decisions (3) .
NCBI Gene ID
388585
Swiss Prot
Q5TA89
Accession Number
NP_001010926
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell
Purification
HES5 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1207 - Raji Cell Lysate
Concentration
1 mg/mL
Buffer
HES5 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
HES5 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
HES5 antibody is human, mouse and rat reactive. At least two isoforms of HES5 are known to exist; this antibody will detect both isoforms.
Symbol
HES5
Positive Control 2
Cat. No. 10-901 - Human Spleen Tissue Slide
NCBI Official Name
Hes family bHLH transcription factor
NCBI Organism
Homo sapiens
Background Reference 01
Katoh M and Katoh M. Identification and characterization of human HES2, HES3, and HES5 genes in silico. Int. J. Oncol. 2004; 25:529-34.
Background Reference 02
Karlsson C, Jonsson M, Asp J, et al. Notch and HES5 are regulated during human cartilage differentiation. Cell Tissue Res. 2007; 327:539-51.
Background Reference 03
Sancho R, Blake SM, Tendeng C, et al. Fbw7 repression by hes5 creates a feedback loop that modulates Notch-mediated intestinal and neural stem cell fate decisions. PLoS Biol. 2013; 11:e1001586.
Other Product Names
Hairy and enhancer of split 5, hes family bHLH transcription factor 5, bHLHb38
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
58219048
Physical Properties
Liquid

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