KLF17 Antibody

• Background:

  KLF17, also known as ZNF393, is a member of the Sp/KLF family of transcription factors (1,2) . KLF17 binds to the promoter and negatively regulates the transcription of Id-1, a key metastasis regulator in breast cancer (3) . Suppression of KLF17 promotes breast cancer cell invasion and epithelial-mesenchymal transition (3) . Down-regulated KLF17 expression is also associated tumor invasion and poor prognosis in hepatocellular carcinoma, suggesting that the level of KLF17 expression can serve as a prognostic indicator (4) .

• NCBI Gene ID:

  128209

• Swiss Prot:

  Q5JT82

• Accession Number:

  NP_775755

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer

• Purification:

  KLF17 antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1464 - Rat Liver Tissue Lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Pig: (81%), Chicken: (79%)

• Buffer:

  KLF17 antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  KLF17 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Fragment:

  IgG

• Specificity:

  KLF17 antibody is human, mouse and rat reactive. At least two isoforms of KLF17 are known to exist; this antibody will only detect the large isoform. KLF17 antibody is predicted to not cross-react with other KLF proteins.

• Symbol:

  KLF17

• NCBI Official Name:

  Kruppel-like factor 17

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Yan W, Burns KH, Ma L, et al. Identification of Zfp393, a germ cell-specific gene encoding a novel zinc finger protein. Mech. Dev. 2002; 118:233-9.

• Background Reference 02:

  Van Vliet J, Crofts LA, Quinlan KG, et al. Human KLF17 is a new member of the Sp/KLF family of transcription factors. Genomics 2006; 87:474-82.

• Background Reference 03:

  Gumireddy K, Li A, Gimotty PA, et al. KLF17 is a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Nat. Cell Biol. 2009; 11:1297-304.

• Background Reference 04:

  Liu FY, Deng YL, Li Y, et al. Down-regulated KLF17 expression is associated with tumor invasion and poor prognosis in hepatocellular carcinoma. Med. Oncol. 2013; 30:425.

• Other Product Names:

  Kruppel-like factor 17, zinc finger protein 393, ZNF393, Zfp393

• Tested Applications:

  ELISA, WB, IHC-P

• Protein ID:

  104294874

• Physical Properties:

  Liquid