KLF12 Antibody

• Background:

  Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].

• NCBI Gene ID:

  11278

• Swiss Prot:

  Q9Y4X4

• Accession Number:

  Q9Y4X4

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This KLF12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 283-312 amino acids from the C-terminal region of human KLF12.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  44 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  KLF12

• NCBI Official Name:

  Krueppel-like factor 12

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

• Background Reference 02:

  Eyre, S., et al. Ann. Rheum. Dis. 69 (7) :1407-1408 (2010)

• Background Reference 03:

  Wieczorek, S., et al. J. Mol. Med. 88 (4) :413-421 (2010)

• Background Reference 04:

  Petersen, G.M., et al. Nat. Genet. 42 (3) :224-228 (2010)

• Other Product Names:

  Krueppel-like factor 12, Transcriptional repressor AP-2rep, KLF12, AP2REP

• Tested Applications:

  WB

• Protein ID:

  91771555

• Physical Properties:

  Liquid