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WDR61 Antibody

CAT: 0223-7985-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7985-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
WDR61 (WD-repeat-containing protein 61), also known as SKI8 or REC14, is a subunit of the human PAF and SKI complexes, which function in transcriptional regulation and are involved in events downstream of RNA synthesis, such as RNA surveillance (1,2) . PAF1C is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1C (3,4) .
NCBI Gene ID
80349
Swiss Prot
Q9GZS3
Accession Number
NP_079510
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell
Purification
WDR61 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1220 - SK-N-SH Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (93%), Chicken: (79%)
Buffer
WDR61 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
WDR61 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
WDR61 antibody is human, mouse and rat reactive.
Symbol
WDR61
NCBI Official Name
WD repeat domain 61
NCBI Organism
Homo sapiens
Background Reference 01
Zhu B, Mandal SS, Pham AD, et al. The human PAF complex coordinates transcription with events downstream of RNA synthesis. Genes Dev. 2005; 19:1668-73.
Background Reference 02
Zhu B, Zheng Y, Pham AD, et al. Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. Mol. Cell. 2005; 20:601-11.
Background Reference 03
Kim J, Guermah M, and Roeder RG. The human PAF1 complex acts in chromatin transcription elongation both independently and cooperatively with SII/TFIIS. Cell 2010; 140:491-503.
Background Reference 04
Chen Y, Yamaguchi Y, Tsugeno Y, et al. DSIF, the Paf1 complex, and Tat-SF1 have nonredundant, cooperative roles in RNA polymerase II elongation. Genes Dev. 2009; 23) :2765-77.
Other Product Names
WD repeat-containing protein 61, Meiotic recombination REC14 protein homolog, REC14, SKI8
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
13376840
Physical Properties
Liquid

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