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E2F3 Antibody

CAT: 0223-7929-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-7929-01Size:0.02 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The E2F transcription factor 3 (E2F3) is a member of a small family of transcription factors that function through binding of DP interaction partner proteins. E2F3 recognizes a specific sequence motif in DNA and interacts directly with the retinoblastoma protein (pRB) to regulate the expression of genes involved in the cell cycle (1) . Like the related E2F1 and E2F2, E2F3 is essential for cellular proliferation and progression through the cell cycle (2) . Altered copy number and activity of this gene have been observed in a number of human cancers (3) .
NCBI Gene ID
1871
Swiss Prot
O00716
Accession Number
NP_001940
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
E2F3 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1369 - Human Lymph node Tissue Lysate
Concentration
1 mg/mL
Buffer
E2F3 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
E2F3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
E2F3 antibody is human and mouse reactive. At least three isoforms of E2F3 are known to exist; this antibody will detect only the largest isoform. This antibody is predicted to not cross-react with other members of the E2F transcription factor family.
Symbol
E2F3
Positive Control 2
Cat. No. 11-521 - Human Lymphoid Tissue Tissue Slide
NCBI Official Name
E2F transcription factor 3
NCBI Organism
Homo sapiens
Background Reference 01
Lees JA, Saito M, Vidal M, et al. The retinoblastoma protein binds to a family of E2F transcription factors. Mol. Cell. Biol. 1993; 13:7813-25.
Background Reference 02
Wu L, Timmers C, Maiti B, et al. The E2F1-3 transcription factors are essential for cellular proliferation. Nature 2001; 414:457-62.
Background Reference 03
DeGregori J. The genetics of the E2F family of transcription factors: shared functions and unique roles. Biochim. Biophys. Acta. 2002; 1602:131-50.
Other Product Names
E2F transcription factor 3, E2F-3
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
4503433
Physical Properties
Liquid

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