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NOX3 Antibody

CAT: 0223-7925-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7925-01Size:0.02 mg
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Background
The NOX family of NAPDH oxidases is comprised of seven transmembrane proteins that oxidize intracellular NAPDH/NADH, causing electron transport across the membrane and the reduction of molecular oxygen to superoxide (1) . NOX3 is expressed predominantly in the inner ear and is involved in the biogenesis of otoconia/otolith (2,3) . It has been suggested that NOX3 is activated by the Transient Receptor Potential Vanilloid 1 (TRPV1), and this activity causes increased levels of reactive oxygen species in the inner ear, which in turn leads to STAT1-mediated inflammation and hearing loss (4) .
NCBI Gene ID
50508
Swiss Prot
Q9HBY0
Accession Number
NP_056533
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell
Purification
NOX3 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1210 - HEK293 Cell Lysate
Concentration
1 mg/mL
Buffer
NOX3 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
NOX3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
NOX3 antibody is human and mouse reactive. NOX3 is predicted to not cross-react with other NOX proteins.
Symbol
NOX3
Positive Control 2
Cat. No. 10-401 - Human Kidney Tissue Slide
NCBI Official Name
NADPH oxidase 3
NCBI Organism
Homo sapiens
Background Reference 01
Bedard K and Krause KH. The Nox family of ROS-generating NAPDH oxidases: physiology and pathophysiology. Physiol. Rev. 2007; 87:245-313.
Background Reference 02
Cheng G, Cao Z, Xu X, et al. Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5. Gene 2001; 269:131-40.
Background Reference 03
Paffenholz R, Bergstrom RA, Pasutto F, et al. Vestibular defects in head-tilt mice result from mutations in Nox3, encoding an NADPH oxidase. Genes Dev. 2004; 18:486-91.
Background Reference 04
Mukherjea, Jajoo S, Sheehan K, et al. NOX3 NADPH oxidase couples transient receptor potential vanilloid 1 to signal transducer and activator of transcription 1-mediated inflammation and hearing loss. Antioxidants and Redox Signaling 2011; 14:999-1010.
Other Product Names
NAPDH oxidase 3, NOX-3, GP91-3, MOX2, MOX-2
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
11136626
Physical Properties
Liquid

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