SOX17 Antibody

• Background:

  SOX17 is a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate (1,2) . SOX17 is part of the SoxF subgroup which plays an important role in the differentiation of different cell types, including visceral and definitive endoderm and hematopoietic cell types (3,4) . SOX17 is also essential for acquisition and maintenance of arterial identity (5) .

• NCBI Gene ID:

  64321

• Swiss Prot:

  Q9H6I2

• Accession Number:

  NP_071899

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Stem Cell

• Purification:

  SOX17 antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1211 - HepG2 Cell Lysate

• Concentration:

  1 mg/mL

• Buffer:

  SOX17 antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  SOX17 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Fragment:

  IgG

• Specificity:

  SOX17 antibody is human, mouse and rat reactive. SOX17 is predicted to not cross-react with other SOX proteins.

• Symbol:

  SOX17

• NCBI Official Name:

  RY (sex determining region Y) -box 17

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Kanai Y, Kanai-Azuma M, Noce T, et al. Identification of two Sox17 messenger RNA isoforms, with and without the high mobility group box region, and their differential expression in mouse spermatogenesis. J. Cell Biol. 1996; 133:667-81.

• Background Reference 02:

  Jiang T, Hou CC, She ZY, et al. The SOX gene family: function and regulation in testis determination and male fertility maintenance. Mol. Biol. Rep. 2013; 40:2187-94.

• Background Reference 03:

  Francois M, Koopman P, and Beltrame M. SoxF genes: key players in the development of the cardiovascular system. Int. J. Biochem. Cell Biol. 2010; 42:445-8.

• Background Reference 04:

  Kim I, Saunders TL, and Morrison SJ. Sox17 dependence distinguishes the transcriptional regulation of fetal from adult hematopoietic stem cells. Cell 2007; 130:470-83.

• Other Product Names:

  SOX17 Antibody: VUR3, Transcription factor SOX-17

• Tested Applications:

  ELISA, WB, IF

• Protein ID:

  11967991

• Physical Properties:

  Liquid