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PARK2 Antibody

CAT: 0223-7903-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7903-01Size:0.02 mg
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Background
Parkinson's disease (PD) is a neurodegenerative disease whose symptoms include tremors, rigidity, bradykinesia, and postural instability (1) . Mutations in the PARK2 gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease (2) . The PARK2 protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation (3) . Recent studies have suggested that PARK2 expression reduces the mitochondrial accumulation of the apoptosis protein Bax under basal conditions and directly ubiquitinates Bax, thereby promoting cell survival (4) .
NCBI Gene ID
5071
Swiss Prot
O60260
Accession Number
NP_004553
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience, Apoptosis
Purification
PARK2 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1362 - Human Cerebellum Tissue Lysate
Concentration
1 mg/mL
Buffer
PARK2 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
PARK2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
PARK2 antibody is human specific.
Symbol
PARK2
Positive Control 2
Cat. No. 10-301 - Human Brain Tissue Slide
NCBI Official Name
Parkin RBR E3 ubiquitin protein ligase
NCBI Organism
Homo sapiens
Background Reference 01
Dauer W and Przedborski S. Parkinson's disease: Mechanisms and models. Neuron 2003; 39:889-909.
Background Reference 02
Kitada T, Asakawa S, Hattori N, et al. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature 1998; 392:605-8.
Background Reference 03
Shimura H, Hattori N, Kubo Si, et al. Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase. Nat. Genet. 2000; 25:302-5.
Background Reference 04
Johnson BN, Berger AK, Cortese GP, et al. The ubiquitin E3 ligase parkin regulates the proapoptotic function of Bax. Proc. Natl. Acad. Sci. USA 2012; 109:6283-88.
Other Product Names
PARK2 Antibody: PDJ, PRKN, AR-JP, LPRS2, E3 ubiquitin-protein ligase parkin, Parkinson juvenile disease protein 2, Parkinson disease protein 2
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
169790969
Physical Properties
Liquid

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