PPARGC1A Antibody

• Background:

  The peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A), also known as LEM-6, is a transcriptional coactivator that regulates the genes involved in energy metabolism (1) . PPARGC1A interacts with PPARgamma, which permits the interaction of PPARGC1A with multiple transcription factors. PPARGC1A can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs) . It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination (2) . PPARGC1A may be also involved in the development of obesity (3) .

• NCBI Gene ID:

  10891

• Swiss Prot:

  Q9UBK2

• Accession Number:

  NP_037393

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity

• Purification:

  PPARGC1A antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1419 - Mouse Skin Tissue Lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine: (100%), Pig: (94%)

• Buffer:

  PPARGC1A antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  PPARGC1A antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Fragment:

  IgG

• Specificity:

  PPARGC1A antibody is human, mouse and rat reactive. At least three isoforms of PPARGC1A are known to exist; this antibody will detect all three isoforms.

• Symbol:

  PPARGC1A

• Positive Control 2:

  Cat. No. 1302 - Human Lung Tissue Lysate

• Positive Control 3:

  Cat. No. 1224 - Daudi Cell Lysate

• Positive Control 4:

  Cat. No. 1204 - K562 Cell Lysate

• NCBI Official Name:

  Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Tsuemi T and La Spada AR. PGC-1a at the intersection of bioenergetics regulation and neuron function: from Huntington's disease to Parkinson's disease and beyond. Prog. Neurobiol. 2012; 97:142-51.

• Background Reference 02:

  Kang C and Li Ji L. Role of PGC-1a signaling in skeletal muscle health and disease. Ann. NY Acad. Sci. 2012; 1271:110-7.

• Background Reference 03:

  Liu C and Lin JD. PGC-1 coactivators in the control of energy metabolism. Acta Biochim. Biophys. Sin. 2011; 43:248-57.

• Other Product Names:

  PPARGC1A Antibody: LEM6, PGC1, PGC1A, PGC-1v, PPARGC1, PGC-1 (alpha), LEM6, Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, Ligand effect modulator 6, PGC-1-alpha

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  7019499

• Physical Properties:

  Liquid