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IFIT1 Antibody

CAT: 0223-7757-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7757-01Size:0.02 mg
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Background
The interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) protein is a member of a family of tetratricopeptide repeat-containing proteins whose transcription is upregulated by interferons, virus infection, and molecular patterns such as dsRNA or lipopolysaccharides (1,2) . These proteins have been suggested to induce anti-viral cellular activities in response to infection (2) . Together with the interferon-induced transmembrane protein 1 (IFITM1), IFIT1 inhibits the replication of the Hepatitis C virus, suggesting that it may be useful in the development of therapeutic treatments (3) .
NCBI Gene ID
3434
Swiss Prot
P09914
Accession Number
NP_001539
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Innate Immunity
Purification
IFIT1 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1468 - Rat Small Intestine Tissue Lysate
Concentration
1 mg/mL
Buffer
IFIT1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
IFIT1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
IFIT1 antibody is human, mouse and rat reactive. At least three isoforms of IFIT1 are known to exist. This antibody is predicted to not cross-react with other members of the IFIT protein family.
Symbol
IFIT1
Positive Control 2
Cat. No. 11-801 - Human Small Intestine Tissue Slide
NCBI Official Name
Interferon-induced protein with tetratricopeptide repeats 1
NCBI Organism
Homo sapiens
Background Reference 01
Wathelet M, Moutschen S, Defilippi P, et al. Molecular cloning, full-length sequence and preliminary characterization of a 56-kDa protein induced by human interferons. Eur. J. Biochem. 1986; 155:11-7.
Background Reference 02
Fensterl V and Sen GC. The ISG56/IFIT1 gene family. J. Interferon Cytokine Res. 2011; 31:71-8.
Background Reference 03
Raychoudhuri A, Shrivastava S, Steele R, et al. ISG56 and IFITM1 proteins inhibit hepatitis C virus replication. J. Virol. 2011; 85:12881-9.
Other Product Names
IFIT1 Antibody: C56, P56, G10P1, IFI56, ISG56, IFI-56, IFIT-1, IFNAI1, RNM561, IFI-56K, Interferon-induced protein with tetratricopeptide repeats 1, Interferon-induced 56 kDa protein
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
116534937
Physical Properties
Liquid

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